基本简介

普通外科专家。湖南省浏阳县人。1924年10月11日出生。1949年毕业于国立中央医学院。解放军普通外科研究所所长、主任医师。1996年当选为中国工程院院士。经长期探索与大量动物实验，攻克肠移植技术难关，在防治感染与促进功能恢复、排斥反应的监控等方面创造了新技术、新经验，成功地进行了亚洲首例全小肠移植，使我国成为国际上8个能开展肠移植的国家之一。独造一系列国际最好水平的肠外瘘治疗原则与方法，推广全国。在国内率先研究外科营养支持疗法，结合国情提出一系列系列改进措施，为该项技术在我国推广应用创造了条件，提高了我国危重病人的抢救水平，影响深远。曾获国家科技进步奖二等奖一项，军队科技进步一、二等奖多项，发表论文362篇，主编专著部。

研究方向：外科学总论、胃肠功能障碍

发表论文

1. Zhao J, Wang G, Jiang ZW, Jiang CW, Liu J, Xia CC, Li JS. Patients Administered Neoadjuvant Chemotherapy Could be Enrolled into an Enhanced Recovery after Surgery Program for Locally Advanced Gastric Cancer[J].Chin Med J (Engl), 2018,131(4):413-419.

2. Liu J1, Zou GJ1, Yang L2, Rong S2, Li BQ1, Tong ZH1, Li WQ1, Li JS1.Early Prediction of Persistent Organ Failure by Circulating Endothelial Progenitor Cells in Patients With Acute Pancreatitis[J]. Shock, 2018,50(3):265-272.

3. Zhao J1, Dong JN1, Wang HG1, Zhao M1, Sun J1, Zhu WM1, Zuo LG1, Gong JF1, Li Y1, Gu LL1, Li N1, Li JS1.Docosahexaenoic Acid Attenuated Experimental Chronic Colitis in Interleukin 10-Deficient Mice by Enhancing Autophagy Through Inhibition of the mTOR Pathway[J]. JPEN J Parenter Enteral Nutr, 2017,41(5):824-829.

4. Zhao J1, Hu J1, Jiang Z1, Wang G1, Liu J1, Wang H1, Fang P1, Liu X2, Wang J3, Li J1.Outcome of Discharge Within 72 Hours of Robotic Gastrectomy Using Enhanced Recovery After Surgery Programs[J].J Laparoendosc Adv Surg Tech A. 2018

5. Li Y, Ge Y, Gong J, Zhu W, Cao L, Guo Z, Gu L, Li J .Mesenteric Lymphatic Vessel Density Is Associated with Disease Behavior and Postoperative Recurrence in Crohn's Disease[J].J Gastrointest Surg. 2018

6. Yun L, Zhiwei J, Kehlet H, Gang W, Jiang L, Jieshou L. Is an Extensive ERAS Program Able to Bring a Better Outcome in Contrast With Standard ERAS Program for Laparoscopic Colorectal Cancer Surgery?.Ann Surg. 2018

7. Li X, Yang Q, Shi X, Chen W, Pu N, Li W, Li J. Compound but non-linked heterozygous p.W14X and p.L279V LPL gene mutations in a Chinese patient with long-term severe hypertriglyceridemia and recurrent acute pancreatitis. Lipids Health Dis. 2018, 17(1):144.

8. Li X, Ke L, Dong J, Ye B, Meng L, Mao W, Yang Q, Li W, Li J. Significantly different clinical features between hypertriglyceridemia and biliary acute pancreatitis: a retrospective study of 730 patients from a tertiary center. BMC Gastroenterol. 2018 Jun 19;18(1):89. doi: 10.1186/s12876-018-0821-z.

9. Liu J, Wang H, Li Y, Shi P, Gong J, Gu L, Zhu W, Li J. Anti-mouse CD52 Treatment Ameliorates Colitis through Suppressing Th1/17 Mediated Inflammation and Promoting Tregs Differentiation in IL-10 Deficient Mice. Biol Pharm Bull. 2018 Sep 1;41(9):1423-1429.

10. Wei Y, Zhu F, Gong J, Yang J, Zhang T, Gu L, Zhu W, Guo Z, Li Y, Li N, Li J. High Visceral to Subcutaneous Fat Ratio Is Associated with Increased Postoperative Inflammatory Response after Colorectal Resection in Inflammatory Bowel Disease. Gastroenterol Res Pract. 2018

11. Zhu F, Feng D, Zhang T, Gu L, Zhu W, Guo Z, Li Y, Gong J, Li N, Li J. Toward a More Sensitive Endpoint for Assessing Postoperative Complications in Patients with Inflammatory Bowel Disease: a Comparison Between Comprehensive Complication Index (CCI) and Clavien-Dindo Classification (CDC). J Gastrointest Surg. 2018 May 15.

12. Hu Q, Ren H, Ren J, Liu Q, Wu J, Wu X, Li G, Wang G, Gu G, Guo K, Hong Z, Liu S, Li J. Released Mitochondrial DNA Following Intestinal Ischemia Reperfusion Induces the Inflammatory Response and Gut Barrier Dysfunction.Sci Rep. 2018 May 9;8(1):7350.

13. Cheng W, Zhang S, Wang J, Zhou C, Li Y, Li J. Three-dimensional CT enterography versus barium follow-through examination in measurement of remnant small intestinal length in short bowel syndrome patients. Abdom Radiol (NY). 2018 Apr 26.

14. Hu Q, Ren J, Li G, Wu J, Wu X, Wang G, Gu G, Ren H, Hong Z, Li J. The mitochondrially targeted antioxidant MitoQ protects the intestinal barrier by ameliorating mitochondrial DNA damage via the Nrf2/ARE signaling pathway. Cell Death Dis. 2018 Mar 14;9(3):403. doi: 10.1038/s41419-018-0436-x.

15. Chen G, Ren J, Deng Y, Wu X, Huang J, Wang G, Zhao Y, Li J. An Injectable, Wound-Adapting, Self-Healing Hydrogel for Fibroblast Growth Factor 2 Delivery System in Tissue Repair Applications. J Biomed Nanotechnol. 2017 Dec 1;13(12):1660-1672. doi: 10.1166/jbn.2017.2443.

16. Ge X, Dai X, Ding C, Tian H, Yang J, Gong J, Zhu W, Li N, Li J. Early Postoperative Decrease of Serum Albumin Predicts Surgical Outcome in Patients Undergoing Colorectal Resection.Dis Colon Rectum. 2017,60(3):326-334

17. Guo K, Ren J, Li G, Hu Q, Wu X, Wang Z, Wang G, Gu G, Ren H, Hong Z, Li J. Risk factors of surgical site infections in patients with Crohn's disease complicated with gastrointestinal fistula.Int J Colorectal Dis. 2017,32(5):635-643.

18.Hu Q, Ren J, Wu J, Li G, Wu X, Liu S, Wang G, Gu G, Li J. Elevated Levels of Plasma Mitochondrial DNA Are Associated with Clinical Outcome in Intra-Abdominal Infections Caused by Severe Trauma. Surg Infect (Larchmt). 2017 Jul;18(5):610-618.

19. Chen Y, Zhou J, Li G, Tong Z, Dong J, Pan Y, Ke L, Li W, Li J.Early Spontaneous Abdominal Bleeding is associated with Poor Outcome in Moderate to Severe Acute Pancreatitis Patients: A Propensity Matched Study. Sci Rep. 2017 Feb 22;7:42607

20. Ding Weiwei, Wang Kai, Liu Baochen, Fan Xinxin, Wang Shikai, Cao Jianmin, Wu Xingjiang, Li Jieshou. Open Abdomen Improves Survival in Patients With Peritonitis Secondary to Acute Superior Mesenteric Artery Occlusion. Journal of Clinical Gastroenterology: 2017;51(9):e77-e82.

21. Zhang T, Ding C, Xie T, Yang J, Dai X, Lv T, Li Y, Gu L, Wei Y, Gong J, Zhu W, Li N, Li J.Skeletal muscle depletion correlates with disease activity in ulcerative colitis and is reversed after colectomy. Clin Nutr. 2017 Dec;36(6):1586-1592. doi: 10.1016/j.clnu.2016

22. Ge X, Hu D, Cao Y, Liu Z, Ding C, Tian H, Gong J, Zhu W, Li N, Li J. Procalcitonin in Crohn's disease with fever episodes, a variable to differentiate intra-abdominal abscess from disease flares.Int J Surg. 2016 Dec;36(Pt A):34-39

23.Fan S, Ni X, Wang J, Zhang Y, Tao S, Kong W, Li Y, Li J. High Prevalence of Suboptimal Vitamin D Status and Bone Loss in Adult Short Bowel Syndrome Even After Weaning Off Parenteral Nutrition. Nutr Clin Pract. 2017 Apr;32(2):258-265.

24. Guo Z, Gong J, Li Y, Gu L, Cao L, Wang Z, Zhu W, Li J.Mucosal MicroRNAs Expression Profiles before and after Exclusive Enteral Nutrition Therapy in Adult Patients with Crohn's Disease. Nutrients. 2016 Aug 22;8(8). pii: E519.

25.Guo F, Huang Y, Zhu W, Wang Z, Cao L, Chen A, Guo Z, Li Y, Gong J, Li J. Efficacy and Safety of Endoscopic Balloon Dilation for Upper Gastrointestinal Strictures of Crohn's Disease. Dig Dis Sci. 2016 Oct;61(10):2977-2985

26. Li G, Ren J, Wang G, Hu Q, Wu Q, Wu X, Li R, Guo K, Li Y, Gu G, Ren H, Hong Z, Li J.Disease-related knowledge and smoking behavior of patients with Crohn's disease. Dig Liver Dis. 2016 Sep;48(9):1006-11

27.Li Q, Wang C, Li J , et al. Successful treatment of severe sepsis and diarrhea after vagotomy utilizing fecal microbiota transplantation: a case report. Crit Care 2015;19: 37. IF:5.035；

28.Li Q, Wang C, Li J , et al. herapeutic modulation and reestablishment of the intestinal microbiota with fecal microbiota transplantation resolves sepsis and diarrhea in a patient. Am J Gastroenterol 2014; 109: 1832–1834. IF:9.232；

29.Li Q, Wang C, Li J, et al. Lymphocyte depletion following alemtuzumab induction disrupts intestinal fungal microbiota in cynomolgus monkeys. Transplantation 2014; 98: 951–959. IF:3.535；

30.Li Q, Wang C, Li J , et al.. Dysbiosis of gut fungal microbiota is associated with mucosal inflammation in crohn’s disease. J Clin Gastroenterol 2014; 48: 513–524.IF:3.635；

31.Li Q, Wang C, Li J , et al.Reciprocal interaction between intestinal microbiota and mucosal lymphocyte in cynomolgus monkeys after alemtuzumab treatment. Am J Transplant.2013;13: 899–910. IF:6.394；

32.Li Q, Wang C, Li J, et al. Bacteremia in the patients with acute pancreatitis as revealed by 16S rRNA gene-based techniques. Crit Care Med. 2013; 41:1938–50. IF:6.330；

33.黎介寿，中国实用外科杂志，2018,38(1):25；

34.唐星明.唐刘蕴泉.黎介寿(通讯作者).倡导加速康复外科建设 促进临床教学改革.中华医学杂志，2018,98(28):2217；

35.唐星明.唐刘蕴泉.黎介寿（通讯作者）. 加速康复外科理念提升医院管理能力.中华医院管理杂志，2017,33(1):72；

38.黎介寿.临床医师养成的思考.医学研究生学报，2014,27(9):897;

37.黎介寿.临床研究的体会.中华结直肠疾病电子杂志,2013,2(6):284;

38.黎介寿.首选肠内营养的合理性.肠外与肠内营养，2013，20（6）：321;

39.黎介寿.胃肠手术的“围手术期营养处理”.肠外与肠内营养，2013,20(2:65)。

获奖情况

以第1完成人，获全国科技大会奖1项、国家科技进步一等奖1项、二等奖3项，军队及省部级医、教、研成果一等奖8项。

荣获“何梁何利奖励基金”医学与药学奖、中国医师奖、中国人民解放军专业技术重大贡献奖、总后勤部有突出贡献的医学专家、培养人才先进个人等称号10余次。2009年，中共中央总书记、国家主席、中央军委主席胡锦涛签署命令为黎介寿院士记一等功。领导的团队，2011年被南京军区授予“科技创新模范医疗科室”荣誉称号，2012年被军委四总部授予“全军科技创新群体奖”。2013年获“江苏省科学技术突出贡献奖”。

1996年当选为中国工程院院士。2014年4月国际小行星中心和国际小行星命名委员会命名192178号小行星为“黎介寿星”。

科研项目

973项目，脂类分子代谢对移植物慢性失功的影响，361万

国家自然基金重点项目，肠粘膜屏障损伤、菌群失衡与细菌易形成，160万

全军“十一五”重点课题，损伤控制性外科，120万

“863”课题：小肠移植及上腹部多器官簇移植关键技术及诊疗规范的建立，289万

江苏省科技创新与成果转化（生命健康科技）专项资金项目（BL2012006）：江苏省普通外科临床医学中心，3000万。

YXZXA2016006，江苏省普通外科临床研究中心，1000万元

2014ZDZK002，国家临床重点专科军队建设项目普通外科专项，300万元

AWS11J013全军“十二五”重点课题，严重战创伤病人休外生命支持系统的研发，1500万元

南京军区装备部，车载生命支持系统的研发，400万元

任职情况

1949.07~1950.06 南京中央医院外科 住院医师

1950.07~1954.07 华东军区医院外科 住院医师、总住院医师

1954.08~1979.04 南京总医院普通外科 主治医师、副主任医师

1979.04~1995.06 全军腹部外科中心 主任、主任医师

1982.08~ 第二军医大学外科学兼职教授、硕士、博士生导师、博士后联系导师、第二军医大学外科学兼职教授、南方医科大学兼职教授

1985.08~ 南京大学外科学教授

1993.09~ 南京大学医学院临床学院 副院长

1995.07~ 全军普通外科研究所 所长

2002.02~ 南京大学国家重点学科（外科学） 主任

学术兼职：

曾任全军医学科学委员会副主任委员，南京军区普通外科主任委员，江苏省医学会副会长国际外科学会委员，欧洲肠外与肠内营养学会会员等。